Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens
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چکیده
منابع مشابه
Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.
Clastogens are potential human carcinogens whose detection by genotoxicity assays is important for safety assessment. Although some endogenous genes are sensitive to the mutagenicity of clastogens, many genes that are used as reporters for in vivo mutation (e.g. transgenes) are not. In this study, we have compared responses in the erythrocyte Pig-a gene mutation assay with responses in a gene m...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 2013
ISSN: 1464-3804,0267-8357
DOI: 10.1093/mutage/get022